Change and significance of plasma lipoprotein-associated phospholipase A2 and Lipoprotein(a)levels in atherosclerotic cerebral infraction
10.7619/jcmp.201416005
- VernacularTitle:血浆脂蛋白相关性磷脂酶 A2、脂蛋白（a）在动脉粥样硬化性脑梗死中的变化及意义
- Author:
Guodong CAI
1
;
Yang GU
;
Shengshan LIU
;
Hairong ZHU
Author Information
1. 扬州大学附属兴化市人民医院 神经内科
- Keywords:
atherosclerotic cerebral infraction;
lipoprotein-associated phospholipase A2;
lipoprotein(a)
- From:
Journal of Clinical Medicine in Practice
2014;(16):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between plasma lipoprotein-associated phospholipase A2,lipoprotein(a)and atherosclerotic cerebral infraction(ACI).Methods The carotid plaque stability of 60 cerebral infraction patients were determined by cervical vascular color Doppler ultrasound.Plasma Lp-PLA2 and Lp(a)levels were detected by enzyme linked immunosor-bent assay(ELISL).Scores of neurological impairment were assessed by the National Institute of Health Stroke Scale (NIHSS).Results 44 patients with ACI showed unstable carotid plaques, while 16 patients with ACI showed stable carotid plaques.Compared with control group,the levels of plasma Lp-PLA2 and Lp(a)were higher in ACI group (P <0.05).The levels of plasma Lp-PLA2 and Lp (a )in unstable plaque group were higher than those in stable plaque group (P <0.05).The plasma level of Lp-PLA2 was negatively correlated with neurological impairment (P >0.05).Conclusion Increasing of Lp-PLA2 and Lp(a)are closely related with atherosclerotic cere-bral infarction.In clinic,the risk of cerebral infarction can be predicted by detecting the levels of Lp-PLA2 and LP(a),and it can play an important role in preventing and reducing the recurrence of cerebral infarction.
