Correlation of serum cystatin C with blood pressure：a cross-sectional study of 912 subjects

VernacularTitle:血清胱抑素C与血压水平的关系：912例报告
Author: Haixia CHEN ¹ ; Tiebing WANG ; Qiu YANG ; Shuming TANG
Author Information

1. 深圳市人民医院检验科
Keywords: cystatin C; hypertension; blood pressure
From: Journal of Southern Medical University 2015;(7):1055-1058
CountryChina
Language:Chinese
Abstract: Objective To study the association between serum cystatin C level and blood pressure. Methods We conducted a cross-sectional study of 912 subjects randomly sampled from a cohort visiting for routine physical examinations. The epidemiological data were obtained using questionnaires and from the database of physical examination results. Pearson analysis and multiple stepwise regression analysis were used to analyze the relationship between blood pressure and cystatin C. Results The levels of serum cystatin C differed significantly among the normotensive, prehypertensive, and hypertensive subjects (P<0.05). Pearson analysis revealed that regardless of gender, serum cystatin C was positively correlated with SBP, DBP, MAP, BMI, TC, TG, LDL-C, UA and BUN (P<0.05). With MAP, SBP and DBP as dependent variables, multiple stepwise regression analysis of the factors affecting blood pressure indicated that cystatin C had the strongest effect on SBP and MAP (P<0.05) but did not significantly affect DBP (P>0.05). Conclusion Serum cystatin C level is significantly correlated with SBP and MAP and can be used as a biomarker for alert of hypertension.