Ovarian response and pregnancy outcome in hyper-responders during repeated in vitro fer-tilization and embryo transfer
- VernacularTitle:高反应患者重复长方案对卵巢反应性及妊娠结局的影响
- Author:
Hao NI
1
;
Sirui HE
;
Hong LI
;
Donghong CHEN
;
Rui HUA
;
Simei CHEN
;
Song QUAN
Author Information
1. 南方医科大学 南方医院妇产科生殖医学中心
- Keywords:
in vitro fertilization and embryo transfer;
excessive ovarian response;
long protocol;
repeated cycles
- From:
Journal of Southern Medical University
2015;(6):912-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the ovarian response and pregnancy outcomes in patients with excessive ovarian response receiving long-protocol pituitary down-regulation during repeated in vitro fertilization and embryo transfer (IVF-ET). Methods Sixty IVF-ET cycles from January 2008 to December 2011 were analyzed retrospectively. The clinical characteristics were compared between the various treatment cycles. Results Compared with those with the first treatment cycle, the patients receiving repeated cycles had a significantly older age (P<0.001), reduced initial doses of Gn (P=0.049), and moderately lowered estrogen level on the day of hCG administration (E2) (P=0.027) and the number of oocytes retrieved (P=0.030). The high-quality embryo formation rate (P<0.001) and clinical pregnancy rate (P=0.009) were both significantly higher in patients with repeated cycles. The dose for down-regulation, total Gn dose, duration of Gn stimulation, number of two pronuclei (PN), number of fertilized oocyte, and the cancellation rate for a high risk of ovarian hyperstimulation syndrome (OHSS) were all comparable between the two groups (P>0.05). The recurrence rate of ovarian excessive respond was 40%(12/30). Conclusion For patients receiving repeated IVF treatment cycle with a high ovarian response, a smaller initial dose of Gn should be used to minimize the risk of hyper-response and improve the outcome of assisted reproductive treatment.
