Clinical significance of epithelial cellular adhesion molecule expression in esophageal carcinoma
10.7619/jcmp.201415010
- VernacularTitle:上皮细胞黏附分子在食管癌组织中的表达及其临床意义
- Author:
Zhihui ZHANG
1
;
Bo JI
;
Yushu MU
Author Information
1. 泰山医学院附属医院 胸外科
- Keywords:
epithelial cellular adhesion molecule;
esophageal carcinoma;
tumor;
differen-tiation;
survival
- From:
Journal of Clinical Medicine in Practice
2014;(15):32-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of epithelial cellular adhesion molecule (Ep-CAM)expression in esophageal carcinoma.Methods Ep-CAM expression of in 60 cases of esophageal carcinoma、35 cases of atypical hyperplasia and 35 cases of normal esophageal mu-cosa was respectively examined by immunohistochemistry.Results Ep-CAM expression were ob-served with positive in 28.75% of atypical hyperplasia and 90.00% of esophageal carcinoma,but with no positive expression in normal esophageal mucosa.The Ep-CAM expression with positive were significantly differently between degrees of tumor differentiation(P <0.01),lymphatic metas-tasis and 3-year survival(P <0.05).Conclusion The increase of Ep-CAM expression,as a specific index,may has the potential for esophageal cancer diagnosis and prognosis.
