Early intervention with aspirin for preventing preeclampsia in high-risk women：a meta-analysis
- VernacularTitle:妊娠早中期服用阿司匹林对子痫前期高危人群预防作用的系统性评价
- Author:
Shuo YAO
1
;
Huan WU
;
Yanhong YU
Author Information
1. 南方医科大学南方医院妇产科
- Keywords:
aspirin;
preeclampsia;
intrauterine growth retardation;
meta-analysis
- From:
Journal of Southern Medical University
2015;(6):868-873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the effect of early intervention with aspirin for prevention of preeclampsia in high-risk women. Methods A systematic review and meta-analysis were performed based on the principles and methods of Cochrane systematic reviews. Electronic databases were searched for randomized trials comparing aspirin with either placebo or no aspirin. Studies were included when meeting the inclusion criteria that the participants were pregnant women at a high risk of preeclampsia and started aspirin therapy at 16 gestational weeks or earlier, which were assessed by two independent reviewers. Meta-analysis was conducted using Review Manger 5.3 software. Results A total of 5 studies involving 860 participants were included in the final analysis. In the high-risk women, early use of aspirin showed an OR of 0.35 (95%CI 0.17-0.75) for preventing pregnancy-induced hypertension (PIH), 0.75 (95%CI 0.47-0.98) for preeclampsia, 0.53 (95%CI 0.29-0.98) for intrauterine growth retardation, and 0.20 (95%CI 0.08-0.48) for preterm birth;the average birth weight in aspirin intervention group was 107.15 g (95%CI 76.13-138.18, P<0.001) more than that in the control group. Conclusion In high-risk pregnancies, early aspirin intervention starting before 16 weeks of gestation can prevent PIH, preeclampsia, IUGR, and preterm birth and help to increase the birth weight.
