Changes of telemetry electrical activity in the infralimbic cortex of morphine-dependent rats with extinguished drug-seeking behavior
10.3969/j.issn.1673-4254.2015.05.22
- VernacularTitle:吗啡依赖大鼠觅药消退期边缘下区遥测脑电活动的变化
- Author:
Jing LI
1
;
Qunwan PAN
;
Zaiman ZHU
;
Min LI
;
Yu BAI
;
Ran YU
Author Information
1. 皖南医学院 生理教研室
- Keywords:
morphine dependence;
drug-seeking extinction;
infralimbic cortex;
telemetry;
brain electrical activity
- From:
Journal of Southern Medical University
2015;(5):733-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of telemetry electrical activity in the infralimbic cortex (IL) of morphine-dependent rats with extinguished drug-seeking behavior. Methods SD rats were randomly divided into model group and control group and received operations of brain stereotaxic electrode embedding in the IL. The rats in the model group were induced to acquire morphine dependence and then received subsequent extinction training, and the changes of electrical activity in the IL were recorded with a physical wireless telemetry system. Results In rats with morphine dependence, the time staying in the white box was significantly longer on days 1 and 2 after withdrawal than that before morphine injection and that of the control rats, but was obviously reduced on days 1 and 2 after extinction training to the control level. Compared with the control group, the morphine-dependent rats on day 2 following withdrawal showed significantly increased β wave and decreased δ wave when they stayed in the white box but significantly increased δ wave and decreased α wave and β wave when they shuttled from the black to the white box. On day 2 of extinction, the model rats, when staying in the white box, showed significantly decreasedθwave compared with that of the control rats group but decreasedβwave andθwave and increasedδwave compared with those in the withdrawal period. When they shuttled from black to white box, the model rats showed decreased δ wave and increased α wave and β wave compared with those in the withdrawal period. Conclusion Morphine-dependent rats have abnormal changes of electrical activity in the IL in drug-seeking extinction to affect their drug-seeking motive and inhibit the expression and maintenance of drug-seeking behaviors.
