Omics of vector mosquitoes:a big data platform for vector biology and vector-borne diseases
10.3969/j.issn.1673-4254.2015.05.02
- VernacularTitle:蚊虫的组学研究：媒介生物学和传播疾病的大数据分析平台
- Author:
Yang WU
1
;
Lihua XIE
;
Peiwen LIU
;
Xiaocong LI
;
Guiyun YAN
;
Xiaoguang CHEN
Author Information
1. 南方医科大学公共卫生与热带医学学院病原生物学系 暨广东省普通高校新发传染病防治重点实验室
- Keywords:
mosquito;
vector;
genomics;
transcriptomics;
small RNAomics;
vector-borne disease
- From:
Journal of Southern Medical University
2015;(5):625-630
- CountryChina
- Language:Chinese
-
Abstract:
Recently the studies on mosquito genomics, transcriptomics and small RNAomics developed rapidly with the novel biotechnologies of the next generation sequencing techniques. The genome sequences of several important vector mosquitoes including Anopheles gambiae, Culex quinquefasciatus, and Aedes aegypti have been published. The genome sizes vary among the different species of mosquitoes and are consistent with the number of the repeat regions. The released genome sequences facilitate gene cloning and identification as for OBP, OR and dsx genes. Transcriptomics provides a useful tool for functional analyses of the mosquito genes, and using this technique, the molecular basis of mosquito blooding, gland proteins and diapauses have been explored. Studies on small RNAomics suggest important roles of miRNAs and piRNAs in ovary development, blood digestion, and immunity against virus infection. The studies on mosquito omics have generated a big data platform for investigation of vector biology and vector-transmitted disease prevention.
