Assessment of protective effect of mecobalamin and glutathione on oxaliplatin-induced neurotoxicity
10.7619/jcmp.201413039
- VernacularTitle:甲钴胺和谷胱甘肽预防奥沙利铂所致神经毒性的效果分析
- Author:
Xiping ZHU
1
;
Yonglong YU
;
Jian HU
;
Shouyou HU
Author Information
1. 安徽省宁国市人民医院 肿瘤科
- Keywords:
oxaliplatin;
neurotoxicity;
mecobalamin;
glutathione;
precaution
- From:
Journal of Clinical Medicine in Practice
2014;(13):116-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of mecobalamin and glutathione in preventing the neurotoxicity induced by oxaliplatin (L-OHP).Methods A randomized,placebo and control study was made ,in which 9 6 patients with colorectal cancer received L-OHP and 5-Fluorouracil (5-FU)was randomly divided into control group treated with normal saline,mecobalamin group with mecobalamin and glutathione group with glutathione,respectively,32 cases for each.Rate of neurotoxicity and severity was observed by L-OHP-specific neurotoxicity grading and neurological symptom score (NSS).Results Rates of neurotoxicity in control group,mecobalamin group and glutathione group were 90.3%(28 /32),46.7%(14 /32)and 59.4%(19 /32)respectively.After 3-cycle and 6-cycle chemotherapy,the rate of neurotoxicity in degree Ⅱ~Ⅲ was lower in mecobal-amin group than in other groups,but the differences were not significant (P >0.05),whereas NSS score was obviously lower in mecobalamin group than in other groups (P <0.05,P <0.01),but the difference between control group and glutathione group was not significant (P >0.05).Conclu-sion Mecobalamin can prevent the rate and severity of oxaliplatin-induced neurotoxicity.
