Expression of helicase DDX41 in human dental pulp tissues and cells
- VernacularTitle:解旋酶DDX41在人牙髓组织及牙髓细胞中的表达
- Author:
Xiaojun YANG
1
;
Jin HOU
;
Xinzhu LI
;
Jiao HU
Author Information
1. 南方医科大学南方医院口腔科
- Keywords:
helicase;
D-E-A-D-box polypeptide 41;
dental pulp;
type I interferon;
innate immune response
- From:
Journal of Southern Medical University
2015;(4):587-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells. Methods The mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry. Results Strong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts. Conclusion DDX41/STING-dependent TBK1-IRF3-IFN-βsignaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.
