Clinical value of IL-6 and IL-8 in monitoring chorioamnionitis of pregnant women with premature rupture of membrane
10.7619/jcmp.201413017
- VernacularTitle:IL-6、IL-8对监测胎膜早破孕妇绒毛膜羊膜炎的临床价值
- Author:
Xiaohui FU
1
;
Guangkun LI
;
Xiulian LI
Author Information
1. 河北省承德县医院 妇产科
- Keywords:
premature rupture of membrane;
interleukin-6;
interleukin-8;
chorioam-nionitis
- From:
Journal of Clinical Medicine in Practice
2014;(13):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of interleukin-6 (IL-6)and interleukin-8 (IL-8)in monitoring chorioamnionitis of pregnant women with premature rupture of membrane (PROM).Methods Forty-five pregnant women with PROM delivered in our hospital were select-ed as research group,and 30 normal pregnant women in our hospital were collected as control group at the same term.The levels of serum IL-6 and IL-8 in both groups were detected with enzyme-linked immunosorbent assay (ELISA),and the fetal membrane tissues were taken to conduct patho-logical examination after delivery.Results The levels of serum IL-6 and IL-8 in research group were significantly higher than in control group,with statistical significance.According to the patho-logical examination on fetal membrane tissues,28 patients (62.2%)were diagnosed as chorioam-nionitis (infection group),and 17 ones (37.8%)were not (non-infection group).The levels of serum IL-6 and IL-8 in infection group were significantly higher than in non-infection group,in which significant differences were presented.Conclusion Joint detection of IL-6 and IL-8 in serum of pregnant women can be used as the important index for monitoring PROM combined with chorioamnionitis.
