Incorporation of TV regularization in deconvolution for partial volume correction in PET im-aging
- VernacularTitle:基于全变分正则化去卷积的PET部分容积校正
- Author:
Debin HU
1
;
Lijun LU
;
Yuanyuan GAO
;
Houjin ZHANG
;
Yanjiang HAN
;
Chengwei GU
;
Jianhua MA
Author Information
1. 南方医科大学生物医学工程学院
- Keywords:
positron emission tomography;
partial volume correction;
deconvolution;
total variation regularization
- From:
Journal of Southern Medical University
2015;(4):474-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective We propose a method using total variation (TV) regularization in deconvolution for partial volume correction in PET imaging. In the degraded image model, we used TV regularization procedure in Van Cittert (VC) and Richardson-Lucy (RL) deconvolution algorithms. These methods were tested in simulated NCAT images and images of NEMA NU4-2008 IQ phantom and tumor-bearing mouse scanned by Simens Invoen microPET. The simulated experiment and tumor-bearing mouse experiment showed that the algorithms using TV regularization provided superior qualitative and quantitative appearance compared with traditional VC and RL algorithms. When the mean intensity of the tumor increased by (10 ± 1.8)%, the SD increase percentage was decreased from 49.98%to 14.26%and from 42.76%to 4.70%, suggesting the efficiency of the proposed algorithms for reducing PVEs in PET.
