Influence of metoprolol on elderly patients with chronic heart failure and serum IL-12 and BNP levels

VernacularTitle:倍他乐克对老年慢性心力衰竭及血清 IL-12与BNP 水平的影响
Author: Qinguo LU ¹ ; Tao GAO ; Pingping DU ; Mingchen ZHAO ; Zhenfeng LI
Author Information

1. 山东省高密市市立医院内科
Keywords: chronic heart failure; metoprolo; interleukin-12; brain natriuretic peptide
From: Journal of Clinical Medicine in Practice 2014;(13):10-12
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical efficacy of metoprolol on elderly patients with chronic heart failure (CHF)and its influence on serum interleukin-12 (IL-12)and brain natriuretic peptide (BNP)levels.Methods A total of 86 patients with CHF served as study objects and ran-domly divided into observation group and control group,43 cases for each.Routine medicines were given to control group while observational group added with metoprolol for 12 weeks.Clinical effica-cy and changes of serum IL-12 and BNP levels were observed.Results Total response rate in obser-vation group was 93.02%,evidently higher than in control group (P <0.01),and there were sig-nificant differences before and after treatment and between two groups in blood pressure,heart rate and left ventricular ejection fraction (LVEF)(P <0.01).Conclusion Basic therapies concomitant with metoprolol have better clinical efficacy than single application of basic therapies,and can more effectively regulate serum IL-12 and BNP expressions and improve the internal environment of body of elderly patients with CHF.