Changes in portal vein and hepatic vein blood flow volume and their ratio in SD rats during induced carcinogenesis of hepatocellular carcinoma
10.3969/j.issn.1673-4254.2015.03.26
- VernacularTitle:肝癌模型诱导过程中SD大鼠门静脉、肝静脉血流量及两者比值变化
- Author:
An WEI
1
;
Hongtian CHEN
;
Liang LIU
;
Keyi WANG
Author Information
1. 湖南省人民医院超声科
- Keywords:
ultrasonography;
rats;
portal vein;
hepatic vein
- From:
Journal of Southern Medical University
2015;(3):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility and reliability of ultrasonic monitoring of portal vein (PV) and hepatic vein (HV) blood flow volume changes in the process of induced carcinogenesis of hepatocellular carcinoma and the correlation of PV/HV blood flow volume ratio (Qpv/Qhv) with the severity of liver cirrhosis. Methods SD rats with diethylnitrosamine-induced liver carcinogenesis underwent regular liver ultrasound examinations including color flow imaging and pulsed Doppler examination. The main PV and HV blood flow parameters were measured to calculate Qpv/Qhv until successful induction of liver cancer. Results The PV diameter increased significantly with the severity of liver cirrhosis in the rats (P<0.05), and the PV blood flow velocity reduced but the blood flow volume increased significantly in liver cancer and cirrhosis stages (P<0.05). Normal hepatic vein blood flow was significantly greater than that measured in liver cirrhosis and hepatocellular carcinoma stages. The Qpv/Qhv measured in normal rats was significantly lower than that in liver cirrhosis and liver cancer stages, but the ratios were comparable between the latter two stages. Conclusion Ultrasonography is reliable to monitor the change of liver hemodynamics in rats with induced liver carcinogenesis, in which the changes of Qpv/Qhv are correlated with the severity of liver cirrhosis.
