Immunological effect of local ablationcombined with immunotherapy on solidmalignancies
10.1186/s40880-017-0216-5
- Author:
Takahashi YUSUKE
1
;
Matsutani NORIYUKI
;
Nakayama TAKASHI
;
Dejima HITOSHI
;
Uehara HIROFUMI
;
Kawamura MASAFUMI
Author Information
1. Department of General Thoracic Surgery
- Keywords:
Immunotherapy;
Solid malignancies;
Cryosurgery;
Radiotherapy;
Stereotactic body radiotherapy
- From:Chinese Journal of Cancer
2017;36(6):252-257
- CountryChina
- Language:Chinese
-
Abstract:
Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeplyinvolved in tumor progression, metastasis, and response to treatment. Furthermore, several immunotherapeutic trialshave achieved successful results, and the immunotherapeutic agents are available in clinical practice. To enhancetheir demonstrated efficacy, combination of immunotherapy and ablation has begun to emerge. Local ablationshave considerable advantages as an alternative therapeutic option, especially its minimal invasiveness. In addition,local ablations have shown immune-regulatory effect in preclinical and clinical studies. Although the correspondingmechanisms are still unclear, the local ablations combined with immunotherapy have been suggested in the treatmentof several solid malignancies. This article aims to review the published data on the immune-regulatory effectsof local ablations including stereotactic body radiotherapy, cryoablation, radiofrequency ablation, and high-intensityfocusedultrasound. We also discuss the value of local ablations combined with immunotherapy. Local ablations havethe potential to improve future patient outcomes; however, the effectiveness and safety of local ablations combinedwith immunotherapy should be further investigated.
