Effect of transcutaneous electrical acupoint stimulation combined with palonosetron on chemotherapy-induced nausea and vomiting: a single-blind, randomized, controlled trial
10.1186/s40880-017-0176-1
- Author:
Xie JING
1
;
Chen LEI-HUA
;
Ning ZHOU-YU
;
Zhang CHEN-YUE
;
Chen HAO
;
Chen ZHEN
;
Meng ZHI-QIANG
;
Zhu XIAO-YAN
Author Information
1. Department of Integrative Oncology
- Keywords:
Acupuncture;
Electro-acupuncture;
Transcutaneous electrical acupoint stimulation;
Nausea;
Vomiting;
Anorexia
- From:Chinese Journal of Cancer
2017;36(5):213-221
- CountryChina
- Language:Chinese
-
Abstract:
Background: Chemotherapy-induced nausea and vomiting adversely affects the quality of life of patients who receive chemotherapy via intravenous infusion or transcatheter arterial chemoembolization (TACE). This study aimed to investigate the clinical effects of transcutaneous electrical acupoint stimulation (TEAS) on nausea and vomiting Methods: A total of 142 patients who received TACE with cisplatin for primary or metastatic liver cancer were assigned to the active-acupuncture (n= 72) or placebo-acupuncture (n= 70) groups using a covariate-adaptive randomization at a ratio of 1:1. The acupoints Hegu (LI4), Neiguan (P6), and Zusanli (ST36) were stimulated twice daily for 6 days. The effects of TEAS on nausea and vomiting were assessed by using occurrence rate and severity of these symptoms. Anorexia scale and M. D. Anderson Symptom Inventory (MDASI) scores were secondary endpoints and were used to assess the effect of TEAS on patient appetite and quality of life. The safety of the treatments was also monitored. Results: Between the two groups, the differences in occurrence rates and severities of nausea and vomiting after TACE were not signiffcant (allP > 0.05). From the second day after TACE, anorexia scores were signiffcantly lower in the active-acupuncture group than in the placebo-acupuncture group and continued to decrease over time with treat-ment (allP values less than 0.01). On days 0, 1, and 2, the mean MDASI scores for the active-acupuncture group were slightly lower than those for the placebo-acupuncture group, but the differences were not statistically signiffcant (all P > 0.05). No signiffcant differences were found between the two groups in the occurrence rate of any adverse event (P > 0.05). Conclusion: TEAS appears to be a safe and effective therapy to relieve patients' gastrointestinal discomfort after chemotherapy.
