Efficacy of Interferon-alpha2b in Treatment of Warts.
- Author:
Kyung Lok KIM
1
;
Jung Sub YEUM
;
Seong Eon KIM
;
Dea Won KOO
;
Ai Young LEE
Author Information
1. Department of Dermatology, Collage of Medicine, Eulji University, Seoul, Korea. nicos@korea.com
- Publication Type:Original Article
- Keywords:
Natural interferon;
Recombinant interferon;
Warts
- MeSH:
Blister;
Humans;
Incidence;
Injections, Intralesional;
Interferons;
Leukemia, Hairy Cell;
Recurrence;
Sarcoma, Kaposi;
Warts*
- From:Korean Journal of Dermatology
2005;43(10):1326-1331
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGOUND: Interferon-alpha2b has already proven to be effective in the clinical treatment of virus-originated diseases such as hairy cell leukemia, condyloma acuminatum, and AIDS-related Kaposi's sarcoma. The use of recombinant interferon-alpha2b may allow various types of wart to be treated relatively atraumatically and with less incidence of recurrence. OBJECTIVE: We tried to compare the effectiveness and safety of intralesional injections of recombinant interferon-alpha2b with natural interferon-alpha2b in the treatment of patients with various types of wart. METHOD: Patients with more than two warts were treated by injecting the different warts with 0.5 to 1.0X105 IU/1mm3 of recombinant and natural interferon-alpha2b, twice per week for 4 to 20 weeks. The response to treatment was followed up at 36 weeks. RESULTS: At the end of treatment, clearing of the treated warts had occurred in 83.3% of the recombinant interferon-alpha2b group and 91.6% of the natural interferon-alpha2b group. A more rapid cure rate was observed in the natural interferon-alpha2b group than in the recombinant interferon-alpha2b group. The rest showed partial improvement. With evaluation for relapse up to 16 weeks after treatment, warts were found to relapse in 11.1% of both the recombinant and natural interferon groups. CONCLUSION: Intralesional natural interferon-alpha2b has a better therapeutic effect than recombinant interferon-alpha2b, and may be considered as a therapeutic modality of recalcitrant verruca or when it can be anticipated that destructive techniques or blistering agents will not be tolerated.
