Application of dexmedetomidine combined with propofol in patients undergoing painless colonoscopy for colonic polyps resection under Narcotrend monitoring
10.3969/j.issn.1673-4254.2015.02.22
- VernacularTitle:Narcotrend麻醉深度监测下右美托咪定复合丙泊酚在结肠息肉切除术中的应用
- Author:
Jinquan JI
1
;
Gang WANG
;
Ke SUN
;
Guobin ZHOU
;
Zhipeng WANG
;
Yan WANG
Author Information
1. 广东省人民医院//广东省医学科学院麻醉科
- Keywords:
dexmedetomidine;
narcotrend monitoring;
colonic polyps resection
- From:
Journal of Southern Medical University
2015;(2):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective This clinical study was conducted to investigate the effects of dexmedetomidine (DEX) combined with propofol on vital signs and anaesthetic depth in patients. Methods Ninty patients with ASA 1-2 requiring painless colono-scopy for colonic polyps resection were randomized to receive DEX 0.3μg/kg (group D, n=45) followed by propofol 1 mg/kg or propofol 2 mg/kg (group C, n=45), and according to the body activity and operation time, additional doses of propofol (0.2-0.5 mg/kg) were given. The full recovery time,operation time, consumed dose of propofol, mean arterial pressure(MAP), heart rate (HR), hemoglobin oxygen saturation levels(SPO2) and NTI were recorded.Results The SPO2、recover time and the consumed dose of propofol in group D were decreased compared to those in group C (P<0.01). The rate of the body activity in group D was lower than that in group C (P<0.05). The NTI in group C was lower than that in group D (P<0.05). The HR and MAP were similar in both groups. Conclusion Under Narcotrend monitoring, the value of DEX combined with low dose of propofol in colonoscopy for colonic polyps resection is to reach more reasonable depth of anesthesia to reduce adverse responses and the dose of propofol.
