Effects of uterine adenomyosis on clinical outcomes of infertility patients treated with in vi-tro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET)
10.3969/j.issn.1673-4254.2015.02.18
- VernacularTitle:子宫腺肌病对体外受精-胚胎移植临床结局的影响
- Author:
Ting TAO
1
;
Shiling CHEN
;
Xin CHEN
;
Desheng YE
;
Lijuan XU
;
Xiaolong TIAN
;
Yudong LIU
;
Jing NIU
Author Information
1. 南方医科大学南方医院妇产科生殖医学中心
- Keywords:
uterine adenomyosis;
in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET);
clinical outcomes
- From:
Journal of Southern Medical University
2015;(2):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of uterine adenomyosis on the clinical outcomes of infertility patients treated with in vitro fertilization/intracytoplasmic sperm injection- embryo transfer (IVF/ICSI- ET). Methods A retrospective study was conducted of 61 IVF/ICSI-ET cycles as the study group, diagnosed with uterine adenomyosis by transvaginal ultrasound, and 164 IVF/ICSI-ET cycles of patients with tubal infertility as the control group. The baseline characteristics, ovary response and clinical outcomes were compared between the two groups. Results The implantation rate, clinical pregnancy rate and live birth rate decreased significantly in the study group (P<0.05), and early abortion rate increased significantly (P<0.05). For patients with adenomyosis, GnRH-antagonist cycles tended to decrease clinical pregnancy rate and increase abortion rate (25.0% vs 45.0%, P=0.184; 66.7% vs 27.8%, P=0.247), and significantly decrease live birth rate (0% vs 30.8%, P=0.025), compared with GnRHa agonist cycles. Conclusion Uterine adenomyosis decreases implantation rate, clinical pregnancy rate and birth rate, and increases abortion rate significantly in patients with IVF/ICSI-ET. GnRH-antagonist cycles have adverse effects on the outcomes of adenomyosis;GnRH agonist long protocol cycles may increase clinical pregnancy rate and decrease abortion rate.
