Induction chemotherapy forlocoregionally advanced nasopharyngeal carcinoma
10.1186/s40880-016-0157-4
- Author:
Li WEN-FEI
1
;
Chen LEI
;
Sun YING
;
Ma JUN
Author Information
1. Department of Radiation 0ncology
- Keywords:
Nasopharyngeal carcinoma;
Induction chemotherapy;
Concurrent chemoradiotherapy
- From:Chinese Journal of Cancer
2016;56(11):567-570
- CountryChina
- Language:Chinese
-
Abstract:
The value of adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) for the treatment of locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. In our recent article entitled “Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial” published in theLancet Oncology, we reported the results of a phase III, multicenter, randomized controlled trial comparing cisplatin, 5?lfuo?rouracil, and docetaxel (TPF) IC plus CCRT versus CCRT alone in patients with T3?4N1/TxN2?3M0 NPC (ClinicalTrials.gov registration number NCT01245959). The IC?plus?CCRT group showed signiifcantly higher 3?year failure?free survival, overall survival, and distant failure?free survival rates than the CCRT?alone group, with an acceptable toxicity proifle. Our study suggests that adding TPF IC to CCRT could increase survival rates and reduce distant failure in patients with locoregionally advanced NPC. However, long?term follow?up is required to assess the eventual effcacy and toxicity of this strategy, and a more accurate method to determine prognosis is needed to enable better tailoring of treatment strategy for individual patients.
