Chromatin remodeling factor LSH affects fumarate hydratase asa cancer driver
10.1186/s40880-016-0138-7
- Author:
Liu SHUANG
1
;
Tao YONGGUANG
Author Information
1. Center for Medicine Research
- Keywords:
Lymphocyte-speciifc helicase (LSH);
Epithelial-mesenchymal transition (EMT);
E-Cadherin;
ZO-1;
Vimentin;
Tricarboxylic acid cycle intermediates;
Inhibitor of nuclear factor kappa-B kinase alpha (IKKα);
G9a
- From:Chinese Journal of Cancer
2016;35(10):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Cancer metabolism and epigenetic alteration are two critical mechanisms for tumorigenesis and cancer progres?sion; however, the dynamic interplay between them remains poorly understood. As reported in the article entitled “Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase,” which was recently published inCancer Research, our group examined the physiological role of lymphocyte?speciifc heli?case (LSH) in nasopharyngeal carcinoma (NPC) by focusing on cancer progression and the tricarboxylic acid cycle. We found that LSH was overexpressed in NPC, and its expression associated with Epstein?Barr virus infection. We also found that LSH directly suppressed fumarate hydratase (FH), a key component of the tricarboxylic acid cycle, in combination with euchromatic histone?lysine N?methyltransferase 2 (EHMT2), also known as G9a. Depletion of FH promoted epithelial?mesenchymal transition (EMT). Moreover, LSH controlled expression of tricarboxylic acid cycle intermediates that promote cancer progression, including EMT, through activation by inhibitor of nuclear factor kappa?B kinase alpha (IKKα), a chromatin modiifer and transcriptional activator. Our study showed that LSH plays a critical role in cancer progression, which has important implications for the development of novel strategies to treat NPC.
