The rationale forpreventing cancer cachexia：targeting excessive fatty acid oxidation
10.1186/s40880-016-0129-8
- Author:
Qian CHAO-NAN
1
Author Information
1. Department of Nasopharyngeal Carcinoma
- Keywords:
Cachexia;
Cancer;
Fatty acid oxidation
- From:Chinese Journal of Cancer
2016;35(7):337-338
- CountryChina
- Language:Chinese
-
Abstract:
Cachexia commonly occurs at the terminal stage of cancer and has largely unclear molecular mechanisms. A recent study published inNature Medicine, entitled “Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia,”reveals that cachectic cancer cells can secrete multiple cytokines that induce excessive fatty acid oxidation, which is responsible for muscle loss in cancer cachexia. Inhibition of fatty acid oxidation using etomoxir can increase muscle mass and body weight in cancer cachexia animal models. The usage of stable cachexia animal models is also dis?cussed in this research highlight.
