Association between single nucleotide polymorphism of adenylyl cyclase 3 and essential hypertension
10.3760/cma.j.issn.0253-3758.2016.07.008
- VernacularTitle:腺苷酸环化酶3基因多态性与原发性高血压的关联研究
- Author:
Yun CHEN
1
;
Yiwei GONG
;
Xiaoqin ZHOU
;
Hongxun XU
;
Lei YANG
;
Yinyin WU
Author Information
1. 310018,杭州师范大学医学院预防医学系
- Keywords:
Hypertension;
Polymorphism,single nucleotide
- From:
Chinese Journal of Cardiology
2016;44(7):594-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the tag single nucleotide polymorphism (tag SNP) of the adenylyl cyclase 3 (ADCY3) and the essential hypertension (EH).Methods From April to July 2013,a total of 1 061 subjects diagnosed with EH and 1 218 control subjects were recruited from Ningbo,Zhejiang Province.Information was collected by face-to-face interview.Twelve tag SNPs were detected by ligase detection reaction technique.Results After adjusted for age,gender,body mass index and other related factors,logistic regression analysis showed that 3 loci (rs11689546,rs7593130,rs2241759) were associated with EH.AG genotype of rs11689546 was associated with 0.494 times lower risk of EH (OR =0.494,95％ CI0.246-0.993;compared with AA genotype).CT genotype of rs7593130 was associated with 1.596 times higher risk of EH (OR =1.596,95％ CI 1.009-2.524;compared with TT genotype),and CT/CC genotype of rs7593130 was associated with 1.627 times higher risk of EH (OR =1.627,95％ CI 1.034-2.559;compared with TT genotype).AG genotype of rs2241759 was associated with 0.669 times lower risk of EH (OR =0.669,95％ CI 0.503-0.891;compared with AA genotype),and CT/CC genotype of rs2241759 was associated with 0.687 times lower risk of EH (OR =0.687,95％ CI 0.518-0.911;compared with TT genotype).Conclusion The polymorphisms of ADCY3 are associated with lower (G allele of the rs11689546 locus and G allele of the rs2241759 locus) or higher (C allele of the rs7593130 locus) risk of essential hypertension.
