Association between genetic variants in the adiponectin gene and premature myocardial infarction
10.3760/cma.j.issn.0253-3758.2016.07.005
- VernacularTitle:脂联素基因多态性与早发心肌梗死的相关性研究
- Author:
Min ZHANG
1
;
Yu PENG
;
Shuzheng LYU
Author Information
1. 100029,首都医科大学附属北京安贞医院心内科
- Keywords:
Myocardial infarction;
Adiponectin;
Polymorphism,single nucleotide
- From:
Chinese Journal of Cardiology
2016;44(7):577-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between adiponectin gene polymorphisms and premature myocardial infarction (PMI).Methods A total of 306 PMI patients of Beijing Anzhen Hospital were identified from March 2013 to January 2015 using the case-control method,412 patients with normal coronary angiography results served as the control group.17 single nucleotide polymorphisms (SNPs) in adiponectin gene were selected and genotyped using mass spectrometry.The Chi-squared test was used to compare allele and genotype frequencies between PMI and control groups.The plasma adiponectin concentrations were measured using enzyme-linked immunoassay,and the relationship was analyzed between adiponectin level and SNPs.Results There was no significant difference in allele frequencies and in genotype frequencies between PMI patients and controls (P ＞0.05).Multivariate logistic regression models were used to estimate the correlation in additive,dominant and recessive genetic models,respectively.Analysis showed that rs2241766T ＞ G was significant associated with PMI risk in a addition model in Chinese Han population(OR =1.446,95％ C1 1.006-2.079,P =0.035),and rs12629945G ＞ A was significant association with PMI risk in a dominant model in Chinese Han population(OR =1.609,95％ CI 1.006-2.573,P =0.041).Adiponectin levels in PMI group were significantly lower than in control group ((863.3 ± 112.8)μg/L vs.(910.4 ± 117.1) μg/L,P =0.042).Adiponectin levels were significantly lower in patients with the homozygous mutation genotype (GG) compared to patients with the heterozygote mutant and wild type genotypes (GT + TT) in adiponectin gene rs2241766 T ＞ G polymorphisms ((859.4 ± 98.1) μg/L vs.(908.9 ± 113.1) μg/L,P =0.032).Conclusion The rs2241766T ＞ G and rs12629945G ＞ A polymorphisms in the adiponectin gene were associated with PMI in Chinese Han population.Rs2241766T ＞ G polymorphisms is linked with lower plasma adiponectin levels,and increased risk of PMI.
