Expression level and significance of T cell subgroups in the peripheral blood of patients with primary Sj?gren′s syndrome
10.7619/jcmp.201409011
- VernacularTitle:T 细胞亚群在原发性干燥综合征患者外周血中的表达水平及其意义
- Author:
Hong ZHANG
1
;
Hongtao FAN
;
Fang HE
;
Sha MA
;
Song JIN
Author Information
1. 云南省第一人民医院 风湿免疫科
- Keywords:
primary Sj?gren′s syndrome;
T cell subgroups;
expression;
significance
- From:
Journal of Clinical Medicine in Practice
2014;(9):41-43,54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression levels and significance of T cell subgroups in the peripheral blood of patients with primary Sj?gren′s syndrome (PSS).Methods Flow cytometer was applied to detect CD3 +,CD3 +CD4 +CD8 -,CD3 +CD4 -CD8 +,CD3 +CD4 -CD8 - and CD4 +CD25 +high expression levels in 32 PSS patients (observation group)and another 35 healthy people tak-ing physical examination (control group),which were then compared between groups.Results There were no significant differences between two groups in CD3 + and CD3 + CD4 - CD8 + expressions (P >0.05).The ratios of CD4 +/CD8 + and CD3 +CD4 +CD8 - subgroups increased evidently (P <0.01), while those of CD3 + CD4 - CD8 - double-negative T cells and CD4 + CD25 +high subgroup decreased markedly in observation group (P <0.01).Conclusion T cell subgroup expressions are abnormal in PSS patients,and over proliferation and infiltration of CD4 + cells is the risk factor of auto-immunologi-cal diseases,while the decrease of CD3 +CD4 -CD8 - double-negative T cells and CD4 +CD25 +high sub-group can lead to the damage of body immunological tolerance,which may be one of the important fac-tors for the development of PSS.
