Impact of recipient/donor killer cell immunoglobulin- like receptor gene mismatch on outcomes of renal transplant
10.3969/j.issn.1673-4254.2014.12.11
- VernacularTitle:KIR基因错配对肾移植临床疗效的影响
- Author:
Xiaoyou LIU
1
;
Zhengyao JIANG
;
Min LUO
;
Lulu XIAO
;
Shaojie FU
Author Information
1. 南方医科大学珠江医院器官移植中心
- Keywords:
kidney transplantation;
killer cell immunoglobulin-like receptors;
genes mismatch;
acute rejection
- From:
Journal of Southern Medical University
2014;(12):1763-1767
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of killer cell immunoglobulin-like receptor (KIR) gene mismatch on the outcomes of renal transplantation. Methods We collected the data from 111 donor-recipient pairs of kidney transplant and analyzed the status of KIR gene matching, acute rejection (AR), and 1-year and 3-year survival of the recipients who were followed continuously for over 37 months. Results Seventeen KIR genes were expressed in both recipient and donor groups, and the frequency of KIR3DS1 was significantly higher in the recipients than in the donors (38.75% vs 24.66%, OR=2.17, χ2=3.94, P<0.05). The average rate of donor-recipient KIR matching was 82.53%. The donor-recipient KIR2DS1 matching rate was significantly higher in AR group than in no-AR group (85.00%vs 54.95%,χ2=6.19, P<0.05). The rate of donor-recipient KIR AB-AB genotype was significantly higher in AR group than in no-AR group (33.33%vs 8.00%, P<0.05). The 1-and 3-year survival rates was 94.59% and 82.88% in these recipients, respectively. The frequency of donor KIR-AB genotpye was significantly higher in recipients with poor outcomes (57.89%vs 29.63%,χ2=8.19, P<0.05);the frequency of both donor and recipient KIR-AB genotype was also significantly higher in recipients with poor prognoses (36.84% vs 9.78%, χ2=14.87, P<0.05). Conclusions KIR3DS1 may be the susceptible gene associated with uremia. A KIR-AB genotype of either the donor or the recipient can increase the risk of AR and reduce the 1- and 3-year survival rate. This finding can be of ethically importance in choosing a living related donor.
