Expression of phosphorylated caspase-8 in non-small cell lung cancer and the clinical implications
10.3969/j.issn.1673-4254.2014.12.09
- VernacularTitle:磷酸化caspase-8在非小细胞肺癌中的表达及其临床意义
- Author:
Weili MIN
1
;
Zhijun DAI
;
Yinbin ZHANG
;
Xijing WANG
;
Yang ZHAO
Author Information
1. 西安交通大学第二附属医院肿瘤科
- Keywords:
Src;
caspase-8;
phosphorylation;
non-small cell lung cancer
- From:
Journal of Southern Medical University
2014;(12):1753-1757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of phosphorylated caspase-8 by Src in patients with operable non-small cell lung cancer. Methods Src and caspase-8 expressions were tested using immunohistochemistry in non-small cell lung cancer tissues and control lung tissues. The expression of phosphorylated caspase-8 at 380 tyrosine by Src was detected using Western blotting. The disease-free survival (DFS) of patients positive and negative for phosphorylated caspase-8 was analyzed with Kaplan-Meire survival curve. Results No significant difference was found in the positivity rate of caspase-8 or Src between the cancer tissues and control lung tissues (76.3% vs 83.3%, P>0.05; 70.1% vs 66.4%, P>0.05). All the patients with Casp8-and Src-positive cancers were positive for phosphoryalted caspase-8, whose expression rate was significantly higher in the cancer tissues than in the paired control lung tissues (52.4%vs 7.1%, P<0.05). The 2-year DFS was significantly higher in patients negative for phosphorylated caspase- 8 than in the positive patients (32.0% vs 60.3% , P<0.05). Conclusion Phosphorylated caspase-8 may serve as a predictor for a poorer DFS in patients with operable non-small cell lung cancer.
