Future options ofanti-angiogenic cancer therapy
10.1186/s40880-016-0084-4
- Author:
Cao YIHAI
1
Author Information
1. Department of Microbiology
- Keywords:
Angiogenesis;
Cancer therapy;
Anti-angiogenesis;
Vascular endothelial growth factor;
Biomarker
- From:Chinese Journal of Cancer
2016;(2):66-74
- CountryChina
- Language:Chinese
-
Abstract:
In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated signiifcant survival beneifts; however, the addition of an anti-angio-genic component to conventional therapeutic modalities has generally produced modest survival beneifts for cancer patients. Currently, it is unclear why these clinically available drugs targeting the same angiogenic pathways produce dissimilar effects in preclinical models and human patients. In this article, we discuss possible mechanisms of various anti-angiogenic drugs and the future development of optimized treatment regimens.
