Clinical characteristics and outcome of patients with dilated-hypertrophic cardiomyopathy
10.3760/cma.j.issn.0253-3758.2016.04.010
- VernacularTitle:肥厚型心肌病扩张相的临床特点及预后分析
- Author:
Pinrui LI
1
;
Xiaolian LI
;
Fei XU
;
Cheng GOU
;
Mingjie DENG
;
Jinqiu LIU
;
Ke WANG
Author Information
1. 116021,大连医科大学附属第一医院心内科
- Keywords:
Cardiomyopathy hypertrophic;
Prognosis
- From:
Chinese Journal of Cardiology
2016;44(4):327-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To define the clinical characteristics and outcome of patients with dilatedhypertrophic cardiomyopathy (D-HCM).Methods Clinical data of HCM patients hospitalized from January 2002 to December 2015 in our hospital were retrospectively analyzed.Patients were divided into D-HCM and classic HCM patients.The D-HCM patients were followed up by phone.Results A total of 616 consecutive HCM patients were evaluated.Twenty one patients (3.4％) were diagnosed with D-HCM (average age (58.8 ± 10.4) years,13 males).It took (14.2 ± 7.1) years for classic HCM patients to develop D-HCM.Compared to classic HCM patients,D-HCM patients were younger at the time of first HCM diagnosis ((39.7 ± 10.4) years old vs.(48.5 ±9.5) years old,P ＜0.001) and had higher ratio of sudden cardiac death family history (19.0％ (4/21) vs.2.5％ (14/558),P =0.003),more patients of future D-HCM patients had ventricular tachycardia (38.1％ (8/21) vs.5.7％ (32/558),P ＜0.001) and higher TroponinⅠ(66.7％ (14/21) vs.9.3％ (52/558),P ＜ 0.001) before the left ventricular cavity enlargement.Moreover,MLVWH ((24.8 ± 4.2) mm vs.(17.2 ± 3.5) mm,P ＜ 0.001) was significantly thicker and LAD ((39.8 ±5.9) mm vs.(35.2 ± 3.3) mm,P ＜ 0.001) was significantly larger in D-HCM patients than in classical HCM patients.During the(3.8 ± 1.9) years follow up period,12 out of 21 D-HCM patients died (57.1％),5 cases(23.8％)died of severe heart failure and 7 cases(33.3％) died of sudden cardiac death.One patient received heart transplantation.Conclusions Few classical HCM patients progressed into D-HCM in this cohort.Patients diagnosed as HCM at young age,HCM patients with abnormal Troponin Ⅰ and ventricular tachycardia are at higher risk of developing D-HCM.The prognosis of D-HCM is very poor,and heart failure and sudden cardiac death are the main causes of death.
