Impact of premature birth on long term cardio-cerebral vascular events of puerpera
10.3760/cma.j.issn.0253-3758.2014.07.015
- VernacularTitle:早产对产妇远期心脑血管事件的影响
- Author:
Dongqing LI
1
;
Jie TAO
;
Yan DONG
;
Haiyan ZHAO
;
Xinying GAO
;
Chunpeng JI
;
Lijiao WANG
;
Honghu XIANG
;
Shouling WU
Author Information
1. 河北联合大学附属开滦总院心内科
- Keywords:
Premature birth;
Vascular diseases;
Risk factors
- From:
Chinese Journal of Cardiology
2014;(7):598-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of premature birth on long term cardio-cerebral vascular events of puerpera.Methods Ambispective cohort study method was used and 3 659 pregnant women giving birth during October 1976 to December 2008 at Kailuan medical group were included and divided into premature birth(PTB) group (n=226) and non-PTB(NPTB) group (n=3 433) by the history of PTB.Incidence of cardio-cerebral vascular events ( myocardial infarction , cerebral infarction and cerebral hemorrhage ) was obtained during follow-up.Multivariable Cox proportional hazards regression models was used to assess the relative risk of cardio-cerebral vascular events.Results ( 1 ) The childbearing age , proportion of pregnancy-induced hypertension , systolic blood pressure and diastolic blood pressure before delivery were significantly higher while weight and height of newborn were significantly less in PTB group than in NPTB group ( P<0.05 or 0.01 ).( 2 ) There were 71 cardio-cerebral vascular events during the follow-up of (15.19 ±7.75) years.In PTB group, the incidence of cardio-cerebral vascular events and myocardial infarction was 3.23/1 000 person-years and 2.05/1 000 person-years, respectively, while the corresponding incidence was 1.15/1 000 person-years and 0.42/1 000 person-years, respectively in NPTB group( all P <0.05 ).After adjustment for other traditional cardiovascular risk factors , the risk of total cardio-cerebral vascular events, myocardial infarction in PTB group was 2.03 fold(95%CI:1.02-4.04, P=0.002) and 3.11 fold ( 95%CI: 1.18 -8.18, P <0.001 ) higher than in NPTB group.Conclusion PTB is an independent risk factor for total cardio-cerebral vascular events , especially myocardial infarction of puerpera.
