Low fat milk powder containing esterified plant sterols improves the blood lipid profile of adults with hypercholesterolemia
10.3760/cma.j.issn.0253-3758.2014.07.013
- VernacularTitle:植物甾醇酯奶粉对高胆固醇血症患者血脂水平的影响
- Author:
Jianqin SUN
1
;
Danfeng XU
;
Hua XIE
;
Yan WANG
;
Min CHEN
;
Xifeng CHANG
;
Yiru PAN
;
Yuan LIU
;
Huijun XUE
;
Hu ZHAO
;
Yanqiu CHEN
;
Fei XIAO
Author Information
1. 复旦大学附属华东医院临床营养中心
- Keywords:
Hyperlipidemias;
Phytosterols;
Cholesterol,LDL
- From:
Chinese Journal of Cardiology
2014;(7):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact of plant sterol esters ( PSE ) mixed in low fat milk powder (2.5 g of PSE/day) on plasma cholesterol levels in hypercholesterolemic subjects during a 6-week intervention period.Methods In this double-blind, randomized, placebo-controlled study, 59 subjects (19 males, mean age ( 60.28 ±6.98 ) years ) with primary hypercholesterolemia ( fasting LDL cholesterol between 3.4-6.0 mmol/L) were randomly divided into two groups ( treatment group , 2.5 g of plant sterol esters a day, n=30) and placebo group (n=29).Blood samples were collected at week 0, 3 and 6.The primary outcome was change in plasma LDL-cholesterol ( LDL-C).Secondary outcomes were changes in total cholesterol ( TC) , HDL cholesterol ( HDL-C) , triglycerides ( TG) , anthropometry and blood biochemistry.Results LDL-C significantly reduction from baseline ( 4.18 ±0.54 ) mmol/L to ( 3.44 ±0.61 ) mmol/L (-17.7%, P<0.05) at week 3 and (3.35 ±0.39) mmol/L ( -19.9%, P<0.05) at week 6 in the treatment group , whereas in placebo group from ( 4.11 ±0.54 ) mmol/L at baseline to ( 3.47 ±0.60 )mmol/L (-15.57%, P<0.05) and (3.61 ±0.39)mmol/L (-12.17%, P<0.05) at week 3 and week 6, respectively.TC was reduced from ( 6.30 ±0.86 ) mmol/L at baseline to ( 5.92 ±0.75 ) mmol/L (-6.03%, P>0.05 ) at week 3 and ( 5.43 ±0.77 ) mmol/L ( -13.8%, P <0.05 ) at week 6 in treatment group, from (6.20 ±0.76)mmol/L at week 0 to (5.70 ±0.76) mmol/L (-8.06%, P<0.05) at week 3 and (5.84 ±0.75) mmol/L ( -5.81%, P<0.05) at week 6 in placebo group.PSE-enriched milk did not affect plasma HDL-C level and TG level at both week 3 and week 6.After normalization to the placebo group , the treatment group showed significant reduction in LDL-C and total cholesteron after 6 weeks.The observed difference of reduction was 7.69% ( -0.33 mmol/L, P <0.05 ) for LDL-C and 8.00%(-0.51 mmol/L, P<0.05) for TC between the two groups.There were no significant changes in safety parameters , including blood biochemistry tests during the study period.Conclusion Plant sterol ester enriched milk powder is effective in reducing LDL-C among Chinese hypercholesterolemic subjects at a dosage recommended by EFSA.
