Impact of loop diuretics on blood sodium in patients hospitalized for heart failure
10.3760/cma.j.issn.0253-3758.2014.07.012
- VernacularTitle:襻利尿剂对心力衰竭患者血钠的影响
- Author:
Yu GUAN
1
;
Xuesi WU
;
Min XU
;
Jiahui WU
Author Information
1. 100029,首都医科大学附属北京安贞医院心内科
- Keywords:
Heart failure;
Sodium;
Diuretics
- From:
Chinese Journal of Cardiology
2014;(7):582-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the level of blood sodium in patients hospitalized for heart failure with water-sodium retention treated with loop diuretics and risk factors of low blood sodium .Methods We selected 1 378 acute decompensated heart failure patients who visited Anzhen Hospital , and they are treated with loop diuretics , 259 patients with weight loses more than 1 kg in one week was enrolled in the final analysis, and divided into 3 groups:Group A (weight reduction between 1-3 kg), Group B(weight reduction between 3-5 kg)and Group C(weight reduction over 5 kg).Blood sodium, creatinine and uric acid were compared among groups and risk factors of low blood sodium were analyzed .Results Blood sodium was similar before and post loop diuretics treatment in Group A , and reduced in group B ( (138.28 ± 3.73) mmol/L vs.(139.34 ±3.66) mmol/L, P<0.05) and in Group C((137.60 ±4.07) mmol/L vs.(139.44 ±4.12 ) mmol/L, P <0.05 ).Forty-six ( 17.8%) patients developed hyponatremia post loop diuretics treatment.Duration of loop diuretics use was the independent risk infector for hyponatremia (OR=1.191, 95%CI 1.010-1.385).Conclusions Loop diuretics use is safe for treating hospitalized patients for heart failure with water-sodium retention and the risk of developing hyponatremia is low.Duration of loop diuretics use is the independent risk factor of hyponatremia .
