Expression of hepatitis B virus surface antigen in 120 Hodgkin's lymphoma patients
- Author:
Qiu MIAO-ZHEN
1
,
2
;
Ruan DAN-YUN
;
Wang ZHI-QIANG
;
Luo HUI-YAN
;
Teng KAI-YUAN
;
Xia ZHONG-JUN
;
Lu YUE
;
Huang HUI-QIANG
;
Jiang WEN-QI
;
Xu RUI-HUA
Author Information
1. State Key Laboratory of Ontology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060,P.R.China
2. Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060,P.R.China
- Keywords:
Hodgkin's lymphoma;
hepatitis B virus;
surface antigens;
survival time
- From:Chinese Journal of Cancer
2010;29(8):735-740
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective:Little is known about the incidence of hepatitis B virus(HBV)infection in Hodgkin's lymphoma patients.This study was to evaluate the impact of HBV infection on the survival of Hodgkin's lymphoma patient.Methods:Clinical data of 120 Hodgkin's lymphoma patients treated at the Sun Yat-sen University Cancer Center between January 2004 and October 2007 were collected.The impact of prognostic factors including HBV infection on survival was examined by univadate and multivariate analyses.A log-rank test was used for univadate analysis and the Cox proportional hazards regression model was used for multivadate analysis.Results:Of the 120 patients,18(15.0%)were hepatitis B virus surface antigen(HBsAg)-positive.The HBsAg-positive patients had lower 5-year survival rate than did the HBsAg-negative ones(66.9% vs.91.3%,P=0.006).When the patients were divided into early-stage(Ⅰ+Ⅱ)and advanced-stage(Ⅲ+Ⅳ)groups,the 5-year survival rate was significantly different between the HBsAg-positive and-negative patients in early-stage group(64.8% vs.96.0%,P＜0.001),while not significantly different in advanced-stage group(75.0% vs.64.8%,P=0.667).Both univariate and multivariate analyses showed that radiotherapy and HBV infection were independent prognosis factors for the patients with early-stage Hodgkin's lymphoma (P=0.006 and 0.014,respectively).Conclusions:The incidence of HBV infection is similar between Hodgkin's lymphoma patients and normal population.HBV infection is an independent prognosis factor for survival in the patients with early-stage Hodgkin's lymphoma.
