The effect of oversized occluder on endothelialization after percutaneous closure of experimental atrial septal defect in dogs
10.3760/cma.j.issn.0253-3758.2014.07.007
- VernacularTitle:过大房间隔缺损封堵器对犬术后内皮化的影响
- Author:
Tingting ZHANG
1
;
Yushun ZHANG
;
Chen WAN
;
Gesheng CHENG
;
Jun WANG
;
Xumei HE
;
Yajuan DU
Author Information
1. 710061,西安交通大学医学院第一附属医院心内二科
- Keywords:
Heart septal defects,atrial;
Heart catheterization;
Endothelium
- From:
Chinese Journal of Cardiology
2014;(7):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of oversized occluder on endothelialization post percutaneous closure of experimental atrial septal defect ( ASD) in dogs.Methods ASD was established with the help of transthoracic echocardiography in 18 dogs.ASD size was ( 6.0 ±0.2 ) mm.Dogs were randomly divided into normal size group ( implanted with 8 mm occlude , n =9 ) and oversized group (implanted with 12 mm occluder, n =9).Dogs were randomly killed at 3, 6 and 14 months after percutaneous closure.The endothelialization process on device surface was observed by scanning electron microscope.Results Four animals died around 1 month post procedure.Microscopic sections from normal group showed nearly complete endothelialization at 3 months after device implantation and complete endothelialization at 6 and 14 months after device implantation.While microscopic sections showed lack of endothelialization at 3 months post implantation , nearly endothelialization at 6 months, and complete endothelialization at 14 months after device implantation in oversized group.Conclusion Incomplete endothelialization of occluder surface is observed at 6 months after implantation of an oversized ASD occluder device in this model.
