CXCR7 in tumorigenesis and progression
- VernacularTitle:CXCR7与肿瘤的发生、发展
- Author:
Hou KA-LIN
1
;
Hao MIN-GANG
;
Bo JUAN-JIE
;
Wang JIAN-HUA
Author Information
1. 上海交通大学医学院附属仁济医院
- Keywords:
CXCR7;
chemokine;
tumorigenesis;
progression
- From:Chinese Journal of Cancer
2010;29(4):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Chemokines,a family of small cytokines,were initially characterized as proinflammatory chemoattractant cytokines that regulated cell trafficking and adhesion.Today,attention focuses on chemokines because evidence shows that they play a critical role in tumor initiation,promotion,and progression.CXCR7,a seven-transmembrane G-protein-coupled CXC chemokine receptor,has recently been identified as binding with high affinity to chemokines CXCL11(I-TAC)and CXCL12(SDF-1).In this review,we highlight the current knowledge about the role of CXCR7 in the biologic processes of cancer,including cancer growth,survival,adhesion,invasion,metastasis,angiogenesis,and progression.The use of peptides,small molecules,antibodies,or small interfering RNA to target CXCR7 shows promise as new potential avenues for the treatment of cancer.
