Changes of blood lipid levels in patients with multiple myeloma and its clinical significance
10.7619/jcmp.201407038
- VernacularTitle:多发性骨髓瘤患者血脂水平的变化及其临床意义
- Author:
Congcong MA
1
;
Yanqin LIU
Author Information
1. 沈阳军区总医院 血液内科
- Keywords:
multiple myeloma;
changes of blood lipid;
clinical stage;
chemotherapy
- From:
Journal of Clinical Medicine in Practice
2014;(7):113-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of blood lipid in the patients with multiple myeloma (MM)and the relationship with clinical stage.Methods 112 initially-diagnosed patients with MM and 80 healthy people were respectively as MM group and normal control group.The lev-els of blood lipid before chemotherapy in two groups and MM patients with different clinical stages as well as the levels before and after chemotherapy were compared.Triglyceride (TG),total choles-terol (TC),high density lipoprotein cholesterol (HDL-C)and low density lipoprotein cholesterol (LDL-C)were included.Results Before chemotherapy,the levels of TC,HDL-C and LDL-C in MM group were significantly lower than that in normal control group,but the difference was not significant compared with TG levels.The levels of TC,HDL-C and LDL-C in phase Ⅲ and LDL-C in phase Ⅱ were all significantly lower than that in normal control group,and the difference was not significant compared with the levels of blood lipid in phase Ⅰ.After 2 courses of chemotherapy,the levels of TC and HDL-C in effectively treated patients were obviously higher than that before chemotherapy.Conclusion The level of blood lipid is helpful to diagnose patients with MM and to evaluate the clinical staging and prognosis.
