The value of radiotherapy in patients with T1 and T2 breast cancer with one to three positive nodes after modified radical mastectomy
- VernacularTitle:术后放疗对1～3个腋淋巴结阳性的T1～T2期乳腺癌患者预后的影响
- Author:
Qiao XUE-YING
1
;
Song YU-ZHI
;
Geng CUI-ZHI
;
Gao WEI
;
Li CHUN-XIAO
;
Zhou ZHI-GUO
Author Information
1. 河北医科大学第四医院
- Keywords:
Breast cancer;
modified radical mastectomy;
postoperative radiotherapy;
positive nodes;
prognosis
- From:Chinese Journal of Cancer
2010;29(4):481-486
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: The role of adjuvant radiotherapy to the regional nodes in women with T1-T2 breast cancer and one to three positive nodes is controversial.This study compared and analyzed the prognosis of patients with T1-T2 breast cancer with one to three positive nodes after modified radical mastectomy with or without postoperative radiotherapy.Methods: The cases of 434 women patients with T1 to T2breast cancer with one to three positive lymph nodes after modified radical mastectomy were reviewed,of which 196 patients received postoperative radiotherapy and 238 patients did not.The ipsilateral chest wall and supraclavicular fossa were irradiated with doses of 46-50 Gy in 23-25fractions.Results: For all patients,the 3-and 5-year rates of overall survival(OS)were 94.7% and 85.7% respectively,local control(LC)96.5% and95.6% respectively,and disease-free survival(DFS)89.3% and 82.3%respectively.The 3-and 5-year OS rates for patients without radiotherapy were 92.7% and 97.1% and for those with radiotherapy were 82.4% and89.2%,both with significant differences(P=0.039).The 3-and 5-year LC rates for patients without radiotherapy were 94.8% and 98.4% and for those with radiotherapy were 93.6% and 97.7%,again with significant differences(P=0.041).The 3-and 5-year DFS rates for patients without radiotherapy were 87.8% and 91.3% and for patients with radiotherapy were 78.5% and86.1%(P=0.047).Conclusion: Postoperative radiotherapy confers better rates of OS,LC,and DFS in patients with T1-T2 breast cancer with one to three positive nodes after modified radical mastectomy.
