Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma
- VernacularTitle:淋巴脉管间隙浸润对早期宫颈鳞癌预后的影响
- Author:
Yan MING
1
,
2
;
Zhang YAN-NA
;
He JIE-HUA
;
Sun XUE-MING
;
Sun JIN-RUI
Author Information
1. 华南肿瘤学国家重点实验室,广东,广州,510060
2. 中山大学肿瘤防治中心妇科,广东,广州,510060
- Keywords:
Squmous cervical carcinoma;
lymph vascular space invasion;
prognosis
- From:Chinese Journal of Cancer
2010;29(4):468-474
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: In the past decade,no remarkable improvement has been made in the 5-year survival of cervical cancer patients.This study was to explore the influence of lymph vascular space invasion(LVSI)on the prognosis of patients with early-stage cervical squamous cell carcinoma.Methods: A total of 111 eligible patients with FIGO stage ⅠB andⅡA cervical squamous cell carcinoma underwent radical hysterectomy and pelvic lymphadenectomy at Sun Yat-sen University Cancer Center between January 1995 and December 2002.The histopathological slides of the 111patients were reviewed by a senior gynecological pathologist.LVSI,invasion depth,tumor differentiation and lymph node metastasis were evaluated.Results: LVSI was present in 62 patients.The univariate analysis showed that the risk factors of overall survival(OS)included positive LVSI(P=0.019)and lymph node metastasis(P=0.002),while the risk factors of progression-free survival(PFS)included LVSI(P=0.029),lymph node metastasis(P=0.002),SccAg value(P=0.018),invasion depth(P=0.022)and positive surgical margin(P=0.002).The multivariate analysis showed that lymph node metastasis was the independent prognostic factor of OS(P=0.015),while lymph node metastasis and positive surgical margin were the independent factors of PFS(P=0.006,P=0.006).LVSI was correlated with lymph node metastasis(P=0.011).Conclusion: Whether LVSI is an independent prognostic factor of early-stage cervical squamous cell carcinoma cannot be determined currently while LVSI is a risk factor of metastasis and relapse.
