The relationship of prognosis to surgery and pathologic characteristics of stage Ⅳ(MO)gastric cancer patients
- VernacularTitle:无远处转移的Ⅳ期胃癌手术、病理特征与预后的关系
- Author:
Xue YING-WEI
1
;
Wei YU-ZHE
Author Information
1. 哈尔滨医科大学附属肿瘤医院
- Keywords:
Gastric cancer;
stage Ⅳ;
surgery;
survival
- From:Chinese Journal of Cancer
2010;29(4):388-392
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: The proportion of stage Ⅳ gastric cancer in the whole gastric cancer population in China is still high.This study was to investigate the surgery and pathologic characteristic and prognostic factors of stage Ⅳ(MO)gastric cancer.Methods: Clinical data of 630patients with pathologically confirmed stage Ⅳ(MO)gastric cancer treated at the Affiliated Tumor Hospital of Harbin Medical University between January1993 and August 2004 were analyzed using Cox proportional hazard model.Of the 630 patients,338 received radical excision and 292 received palliative resection.Results.The overall 1-,3-,and 5-year survival rates were 63.8%,31.4%,and 14.3%,respectively.Univariate analysis showed that Borrmann type,lymphatic metastasis,organ involvement,tumor location,tumor size,pathologic type,radical excision,and other organ excision were significant prognostic factors affecting 1-year survival rate(P<0.05); Borrmann type,lymphatic metastasis,organ involvement,pathologic type,and radical excision affected 3-year survival rate(P<0.05); only organ involvement and pathologic type affected 5-year survival rate(P<0.05).Multivariate analysis showed that pathologic type was independent prognostic factor for poor survival.Conclusions.Radical resection and combined organ resection could prolong the survival of stage Ⅳ(MO)gastric cancer patients.Chemotherapy,radiotherapy and targeted therapy should be considered for individual therapeutic regimen.
