Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1(APE/Ref-1)
- VernacularTitle:APE/Ref-1在肿瘤治疗中的应用前景
- Author:
Zhang YING
1
;
Wang JIAN
Author Information
1. 第四军医大学西京医院
- Keywords:
Apurinic/apyrimidinic endonuclease;
neoplasm;
gene therapy
- From:Chinese Journal of Cancer
2010;29(3):363-369
- CountryChina
- Language:Chinese
-
Abstract:
Apurinic/apyrimidinic endonuclease/redox factor-1(APE/Ref-1),as a type of multifunctional protein,plays an essential role in the base excision repair(BER)pathway,which is responsible for the repair of DNA caused by oxidative and alkylation damage.As importantly,APE/Ref-1 also functions as a redox factor maintaining transcription factors in an active reduced state.APE/Ref-1 stimulates the DNA-binding activity of numerous transcription factors that are involved in cancer promotion and progression,such as AP-1(Fos/Jun),NF-κB,HIF-1α,p53,and others.Based on the structures and functions of APE/Ref-1,we will provide an overview of its activities and explore the budding clinical use of this protein as a target in cancer treatment,and propose that APE/Ref-1 has a great potential for application in clinical research.
