Influence of macrophage migration inhibitory factor on signal transmit mechanism of collagen metabolism in vascular smooth muscle cell
10.7619/jcmp.201407003
- VernacularTitle:巨噬细胞移动抑制因子对血管平滑肌细胞胶原代谢信号转导的影响
- Author:
Ling ZHANG
1
;
Jun LI
;
Aihuan MAI
;
Xinjian LIANG
Author Information
1. 广东省深圳市人民医院 心内科
- Keywords:
macrophage migration inhibitory factor;
smooth muscle cell;
collagen;
signal transmit route;
extracellular signal -regulated kinase
- From:
Journal of Clinical Medicine in Practice
2014;(7):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of macrophage migration inhibitory factor (MIF)on signal transmit route of collagen synthesis in vascular smooth muscle cell (SMC).Methods The expression of signal transmit phosphorylated ERK of SMC in the rat aorta was measured by the western blotting procession after stimulation by MIF,Ang Ⅱ,MIF +PD 98059,AngⅡ +PD 98059. Results The expression of phosphate ERK of the SMC raised significantly after MIF and Ang Ⅱ stim-ulation (P <0.05).The mount of phosphorylated ERK in the Ang Ⅱ group was higher than that in the MIF group.After adding PD 98059,the phosphorylated ERK in both groups decreased significantly (P <0.05).Conclusion Both MIF and Ang II can activate MAPK/ERK route,and it might act in the same signal transmit route of collagen synthesis between MIF effect and Ang II effect.
