Expression and clinical significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma
- VernacularTitle:Ezrin、E-cadherin在食管鳞癌中的表达及临床意义
- Author:
Zhai JIAN-WEN
1
;
Yang XIAO-GANG
;
Yang FU-SHEN
;
Hu JI-GANG
;
Hua WEN-XIA
Author Information
1. 河北工程大学附属医院
- Keywords:
Esophageal neoplasm;
Ezrin;
E-cadherin;
tissue array;
immunohistochemistry
- From:Chinese Journal of Cancer
2010;29(3):343-347
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective:It has been proven that Ezrin protein may interact with E-cadherin protein and take part in metastasis of tumor cells.This study was to investigate the expressions of Ezrin and E-cadherin in esophageal squamous cell carcinoma(ESCC)and their relationship with the clinicopathologic factors,and to analyze their diagnostic values for ESCC.Method:The expression of Ezrin and E-cadherin in 72 specimen of ESCC and the para-cancer normal squamous epithelium was detected using tissue array with SP immunohistochemistry.Their correlations with the clinicopathologic factors were analyzed statistically.Results:The positive rate of Ezrin was significantly higher in ESCC than in para-cancer normal squamous epithelium (90.7%vs.46.0%,P＜0.001);the positive rate of E-cadherin was significantly lower in ESCC than in para-cancer normal squamous epithelium (27.6%vs.97.4%.P＜0.001).Ezrin expression was related to the invasiveness and lymph node metastasis of ESCC(P＜0.05);E-cadherin expression was related to the differentiation and lymph node metastasis of ESCC(P＜0.05).The high expression of Ezrin was related to the low expression of E-cadherin(P＜0.05).Conclusion:The activation of Ezrin and the absence of E-cadherin contributes to the tumorigenesis and metastasis of ESCC.
