Genetic variation in the promoter region of the β2 bradykinin receptor gene is associated with essential hypertension in a Chinese Han population
- VernacularTitle:缓激肽β2受体基因启动子区点突变与高血压病的关系
- Author:
Bing WANG
1
;
Guozhang LIU
;
Aimin DANG
Author Information
1. 中国医学科学院/中国协和医科大学心血管研究所附属北京阜外心血管医院
- From:
Chinese Journal of Cardiology
2001;29(4):203-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective The present study examined the genetic contribution of the human β2 bradykinin receptor gene to essential hypertension and identified the association of a -58T/C polymorphism with essential hypertension in a Chinese Han population. Methods The study consisted of 106 hypertensive subjects and 98 age-and sex-matched controls. The distribution of -58T/C polymorphism was measured in patients and controls by using PCR, SSCP, cloning and sequencing. Results The allelic frequencies were 0.58 for the C allele in 0.42 for the T allele in hypertensive subjects, and 0.46 for the C allele and 0.54 for the T allele in normotensive subjects. The allelic frequencies were in Hardy-Weinberg equilibrium. Significant differences in the genotype distribution (P=0.032) and allelic frequencies (P=0.018) between hypertensive and normotensive subjects were seen. Conclusion These results suggest that -58C allele of the human β2 bradykinin receptor gene may be an independent risk factor for essential hypertension in the Chinese Han population.
