Research progression of CD133 as a marker of cancer stem cells
- VernacularTitle:CD133与肿瘤干细胞研究进展
- Author:
Zhang HUA
1
;
Li SU-YI
Author Information
1. 东南大学附属中大医院
- Keywords:
Stem cell;
cancer stem cell;
CD133
- From:Chinese Journal of Cancer
2010;29(3):259-264
- CountryChina
- Language:Chinese
-
Abstract:
More and more evidences support the cancer stem cells(CSCs)hypothesis,which postulates that CSCs are responsible for tumor initiation,metastasis,recurrence and resistance to treatments.Therefore,they are the targets of antitumor therapy.Sorting CSCs using specific surface markers is the premise of investigating their biological behaviors.Recently,CD133 has been used extensively as a marker for the identification of stem cells from normaI and cancerous tissues.Moreover,CD133-positive(CD133~+)tumor cells associate with the self-renewal,differentiation potentials,signal pathway,drug-resistance,recurrence,and prognosis of tumors.Therefore,CD133~+ cells could be potential targets of antitumor therapy in the future.
