Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization
- VernacularTitle:肝细胞癌经导管动脉化疗栓塞前后磁共振波谱研究
- Author:
Bian DU-JUN
1
;
Xiao EN-HUA
;
Hu DONG-XU
;
Chen XIANG-YU
;
Situ WEI-JUN
;
Yuan SHU-WEN
;
Sun JIAN-LING
;
Yang LI-PING
Author Information
1. 中南大学湘雅二医院
- Keywords:
Liver neoplasm;
proton magnetic resonance spectroscopy;
transcatheter arterial chemoembolization;
choline-to-lipid ratio;
glycogen/ glucose-to-lipid ratio;
glutamine/glutamate-to-lipid ratio
- From:Chinese Journal of Cancer
2010;29(2):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective:Proton magnetic resonance spectroscopy(MRS) of the liver in vivo is in experimental phase. MRS observation on liver cancer after transcatheter arterial chemoembolization (TACE)has seldom been reported.This study was to investigate the value of MRS in assessing the metabolic changes of hepatocellular carcinoma(HCC) after TACE.Methods:Twenty-five consecutive patients with pathologically confirmed HCC received 1 H MRS of all hepatic lesions using 1.5T whole body MR scanner before TACE and at 3-10 days after TACE.Choline-to 1ipid(Cho/Lip), glycogen/gIucose-to-lipid(Glu/Lip), and glutamine/ glutamate-to-lipid(Gix/Lip)ratios were measured and analyzed statistically.Results:The Cho/Lip,Glu/Lip,and Gix/Lip ratios were 0.21±0.08.0.11± 0.05,and 0.28±0.10 before TACE,respectively,and were 0.10±0.08,0.07±0.07,0.18±0.12 after TACE, respectively, with significant differences(P<0.05).Conclusion: Using MRS can evaluate the early metabolic responses of HCC to TACE.
