Prognostic analysis of the patients with stage-Ⅲ esophageal squamous cell carcinoma after radical esophagectomy
- VernacularTitle:Ⅲ期胸段食管鳞癌根治切除术后预后因素分析
- Author:
Hu YI
1
,
2
;
Zheng BIN
;
Rong TIE-HUA
;
Fu JIAN-HUA
;
Zhu ZHI-HUA
;
Yang HONG
;
Luo KONG-JIA
;
Li YONG-FENG
Author Information
1. 华南肿瘤学国家重点实验室,广东,广州,510060
2. 中山大学肿瘤防治中心胸科,广东,广州,510060
- Keywords:
Esophageal carcinoma;
surgery;
prognosis
- From:Chinese Journal of Cancer
2010;29(2):190-195
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: Most patients with esophageal carcinoma have disease in the locally late stage (stage Ⅲ) when first diagnosed,with surgery as the first treatment of choice.This study analyzed the clinical data of patients with esophageal squamous carcinoma after radical esophagectomy and investigated prognostic factors.Methods:The data of 361 patients with esophageal squamous carcinoma who underwent radical esophagectomy and were hospitalized at Sun Yat-sen University Cancer Center between January 1997 and March 2004 were analyzed.The Kaplan-Meier method was used to analyze prognosis,log-rank test was used to compare the groups, and the Cox proportional hazards model was used for multivariate analysis.Results:The 1-,2-,3-,4,and 5-year survival rates were 67.7%,40.6%,27.5%,23.4%,and 20.1%,respectively.Based on univariate analysis,the degree of invasion, rale of lymph node metastasis, number of metastatic regions, number of metastatic lymph nodes,postoperative complications,and duration of surgery were prognostic factors.Based on multivariate analysis,the degree of invasion,rate of lymph node metastasis, and postoperative complications were independent factors for the prognosis.Conclusions:Of all clinical and pathologic factors,the degree of invasion, rate of lymph node melastasis. And postoperative complications were independent factors for the prognosis of patients with stage-Ⅲ esophageal squamous carcinoma after radical esophagectomy.
