Preventive role of 103 Pd-radiative stent on in-stent restenosis in rabbits
10.3760/j:issn:0253-3758.2001.02.013
- VernacularTitle:103Pd同位素支架预防支架内再狭窄的实验研究
- Author:
Yingling ZHOU
1
;
Shuguang LIN
;
Guang LI
Author Information
1. Guangdong Cardiovascular Institute
- From:
Chinese Journal of Cardiology
2001;29(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive role of 103Pd-radiative stent on in-stent restenosis in rabbits. Methods Fifty male New Zealand white rabbits were divided into two groups: control group （balloon injury followed by stent implantation, n=25） and treatment group （balloon injury plus 103Pd-radiative stent implantation, n=25）. At the end of 3-day, 1-week, 2-week, 4-week and 8-week after injury, the animals of the treatment group underwent arterial angiography. All animals in both groups were killed for histomorphometrical and immunohistochemical studies on abdominal arteries. Results Compared with the control group, the inner diameter was greater (P<0.05) in the 8-week subgroup; the rate of neointimal proliferation and vascular stenosis in rabbits received 103 Pd-radiative stent were suppressed and no radioactivity was detected in peripheral blood. Conclusion103 Pd-radiative stent could prevent in-stent restenosis significantly in rabbits.
