Comparison of the short-term efficacy of two inductive chemotherapy regimens for locally advanced nasopharyngeal carcinoma: docetaxal plus carboplatin versus 5-fluorouracil plus carboplatin
- VernacularTitle:多西紫杉醇联合卡铂与氟尿嘧啶联合卡铂治疗局部晚期鼻咽癌近期疗效的比较
- Author:
Lu XING
1
,
2
;
Guo XIANG
;
Hong MING-HUANG
;
Chen QIU-YAN
;
Zeng QI
;
Xiang YAN-QUN
Author Information
1. 华南肿瘤学国家重点实验室,广东,广州,510060
2. 中山大学肿瘤防治中心鼻咽癌科,广东广州,510060
- Keywords:
Nasopharyngeal neoplasm;
docetaxel;
efficacy;
adverse events
- From:Chinese Journal of Cancer
2010;29(2):148-152
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective: The platinum-based chemotherapy combined with 5-fluorouracil (5-FU) is most frequently used for nasopharyngeal carcinoma (NPC), but the efficacy has been maintained at 50%-60%. Docetaxel is an effective drug for head and neck tumors, its administration is simple, and the administration time is short. This study was to compare the short-term efficacy and toxicity between TC regimen (inductive chemotherapy with docetaxol plus carboplatin) and FC regimen (5-FU plus carboplatin) in local advanced NPC so as to provide a new chemotherapeutic regimen for NPC. Methods: Fifty-eight local advanced NPC patients without previous treatment in Sun Yat-sen University Cancer Center were randomly assigned to receive either TC regimen or FC regimen treatment. The short-term efficacy and adverse events were observed. Results: More chemotherapy cycles were finished in TC group than in FC group (3.31 vs. 2.83, P=0.043). There was no significant difference in short-term efficacy and 1-year survival rate between the two groups (P >0.05). More Grades 3-4 neutropenia appeared in TC group than in FC group (72.4% vs. 37.9%,P< 0.05), whereas less thrombocytopenia and emesis occurred in TC than in FC group (P= 0.013 and 0.018, respectively).Conclusions: The short-term efficacy of TC regimen in local advanced NPC is similar to that of FC regimen with tolerable adverse events. But the longterm outcomes and toxicities need to be further investigated.
