Stereotactic radiotheraply——an approach to improve local control of nasopharyngeal carcinoma
- VernacularTitle:立体定向放射治疗:提高鼻咽癌局部控制的有效方法
- Author:
Xiao JIAN-PING
1
;
Xu GUO-ZHEN
Author Information
1. 中国医学科学院北京协和医学院肿瘤医院
- Keywords:
Nasopharyngeal neoplasm;
residual lesions;
stereotactic radiotherapy;
boost irradiation
- From:Chinese Journal of Cancer
2010;29(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is the primary curative treatment of nasopharyngeal carcinoma(NPC)with the dose-response relationship. Local recurrence is one of the major treatment failures. With high accuracy, high dose focus on the tumor, high therapeutic enhancement ratio and low normal tissue dose, stereotactic radiotherapy (SRT) is used as boost irradiation for residual lesions and improves the local control under many different SRT regimens. Residual lesions involving the carotid artery, cavernous sinus and tumor with necrosis are the contraindications to SRT boost irradiation; while the old patients, patients with hypertension, diabetes mellitus, and severe nasopharyngeal infection are the relative contraindications to SRT boost irradiation. Fractionated SRT can spare vessels and nerves better than stereotactic radiosurgery(SRS).SRT can definitely improve the outcome for the boost of NPC residual lesions. Proper patient selection, individualized fractionated regimen, and balance of the benefit of tumor control and the risk of normal tissue damage are of paramount importance to ensure the satisfactory clinical outcome and quality of life.
