Relationship between changes of serum response factor and heart heart failure

VernacularTitle:反式作用因子中血清反应因子变化与心力衰竭关系的研究
Author: Xiaoxia WU ¹ ; Guang ZHI ; Jiajin WU
Author Information

1. Beijinng Hospital of Integrating Traditional Chinese with Western Medicine
From: Chinese Journal of Cardiology 2001;29(1):51-53
CountryChina
Language:Chinese
Abstract: Objective To investigate the relation ship between trans-acting factor and the change of protein expression levels in heart failure. Methods Bioinformationak methods were used to analyze the bindingsites in the 5＇ regulation regions of four genes of the protein expression levels change in heart failure. The serum response factor (SRF) level was determined by innuno-hischemical method. Results Nine trans-transcription factors were inferred to influence these protein expression levels in occurrence and development of heart failure. SRF was selected from the nine factors and assayed. The results showed a higher level of SRF in healthy people, the percentage of anti-SRF positive cardiocytes was(91.6±10.05)%. A lower percentage of SRF in congestive heart failure (CHF) was (28.73±12.79)%. And the level of SRF was associated with the functional class of the New York Heart Association. A relative higher level of SRF was found in the acute myocardial infarction (AMI) (4533±13.30)% than that in CHF and in the healthy. Conclusion It was suggested that the level of SRF plays a regulative role in CHF.