Expression of B7-H1 protein in human pancreatic carcinoma tissues and its clinical significance
10.3321/j.issn:1000-467X.2009.12.017
- VernacularTitle:B7-H1蛋白在人胰腺癌组织中的表达及临床意义
- Author:
Chen XIAO-LING
1
;
Yuan SU-XU
;
Chen CHEN
;
Mao YI-XIANG
;
Xu GANG
;
Wang XIAN-YUAN
Author Information
1. 苏州大学附属第一医院
- Keywords:
pancreatic cancer;
immunohistochemistry;
B7-H1 protein;
prognosis
- From:Chinese Journal of Cancer
2009;28(12):1328-1332
- CountryChina
- Language:Chinese
-
Abstract:
Background and Objective:B7-H1,a member of B7 family,is expressed in tumor cells and has emerged as an important immune modulator capable of suppressing host immunity by inhibiting T cells function.This study was to probe into the correlation between the expression level of B7-H1 protein in pancreatic carcinoma tissues and clinicopathological characteristics and prognosis.Methods:The expression of B7-H1 was measured in 40 cases of pancreatic carcinoma tissues and 10 cases of normal corresponding paracaroinoma tissues by immunohistochemistry.The relationship between the expression level of B7-H1 and clinicopathological characteristics and survival was analyzed.Results:The positive rate of B7-H1 was significantly higher in the tumor tissues [45.00%(18/40)]than in the normal corresponding paracarcinoma tissues[0(0/10)](P<0.05);moreover,B7-H1 expression was significantly associated with the staging of tumor and preoperative serum CA19-9 level(P<0.05).The multivariate cox proportional hazards regression analysis of prognostic factors for overall survival and relapse-free survivalshowed that the expression of B7-H1 was an independent factor for poor prognosis.Conclusion: B7-H1 protein was expressed in human pancreatic carcinoma tissues,and was associated with the prognosis.
